COUPLING OF AUTOPHAGY AND THE MITOCHONDRIAL INTRINSIC APOPTOSIS PATHWAY MODULATES PROTEOSTASIS AND AGEING IN CAENORHABDITIS ELEGANS

Coupling of autophagy and the mitochondrial intrinsic apoptosis pathway modulates proteostasis and ageing in Caenorhabditis elegans

Abstract Mitochondria preserve metabolic homeostasis and integrate stress signals, to trigger cytoprotective, or cell death pathways.Mitochondrial homeostasis and function decline with age.The mechanisms underlying the deterioration of mitochondrial homeostasis during ageing, or in Tea Set age-associated pathologies, remain unclear.Here, we show th

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Redox signaling via oxidative inactivation of PTEN modulates pressure-dependent myogenic tone in rat middle cerebral arteries.

The present study examined the level of generation of reactive oxygen species (ROS) and roles of inactivation of the phosphatase PTEN and the PI3K/Akt signaling pathway in response to an increase in intramural pressure-induced myogenic cerebral arterial constriction.Step increases in intraluminal pressure of cannulated cerebral arteries induced myo

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